Clinical Efficacy of Vitamin D Supplements for the Treatment of Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Wanyan X, Xu J
Hemodialysis international. International Symposium on Home Hemodialysis · 0 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2026-06-07 · Hemodial Int · vol. 30 · issue 3 · pp. 478–485
- Publisher
- Wiley
- Cited
- 1 citation · more than 91% of similar papers · 2.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 23 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Erythropoietin and Anemia Treatment · Iron Metabolism and Disorders
- Keywords
- Anemia, Randomized controlled trial, Kidney disease, Inclusion and exclusion criteria, Vitamin D and neurology, Meta-analysis, Clinical efficacy, Cochrane Library
- MeSH
- humans, anemia, vitamin d, treatment outcome, dietary supplements, female, male, renal insufficiency, chronic
2 authors
From CN
- Xiaodong WanyanFirst Affiliated Hospital of Henan University of Science and Technology
- Jiayun Xu · correspondingFirst Affiliated Hospital of Henan University of Science and Technology
Abstract
Objective
To conduct a meta-analysis of clinical randomized controlled studies related to vitamin D supplements for the treatment of anemia in patients with chronic kidney disease (CKD), to evaluate the clinical efficacy of vitamin D supplements for CKD patients complicated with anemia.
Methods
A literature review of the published literature in both English and Chinese was searched from the Cochrane Library, PubMed, Web of Science, CNKI and Wanfang Data that were published from the inception date to January 2018. Randomized controlled trials (RCTs) eligible for the inclusion and exclusion criteria were selected. The quality of eligible studies was assessed by the Cochrane Risk of Bias tool. Meta-analysis was performed by using Revman 5.3 software.
Results
A total of 12 RCTs comprising 779 patients were included in this meta-analysis, including 383 patients in the experimental group (with vitamin D supplementation) and 396 patients in the control group (without vitamin D supplementation). Meta-analysis showed that vitamin D supplements could significantly increase the hemoglobin (p < 0.01, SMD = 1.24, 95% CI: 1.02-1.45) and lower the dosage of erythropoietin required (p < 0.01, SMD = -0.76, 95% CI: -1.09 to -0.43).
Conclusion
Use of vitamin D supplements can significantly elevate the hemoglobin concentration and reduce the dosage of erythropoietin. However, these findings remain to be validated by large-scale, multi-center, prospective RCTs.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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