Serum vitamin D levels in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis
Jiang M, Wang T, Huang L
Frontiers in endocrinology · 0 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Fundamental Research Funds for the Central Universities
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-06-16 · Front Endocrinol (Lausanne) · vol. 17 · p. 1839319
- Publisher
- Frontiers Media
- Cited
- 0 citations · more than 40% of similar papers · 0.0× the field average
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Ovarian function and disorders · Vitamin D Research Studies · Menstrual Health and Disorders
- Keywords
- Polycystic ovary, Vitamin D and neurology, vitamin D deficiency, Obesity, Meta-analysis, Insulin resistance, Prospective cohort study, Insulin sensitivity
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, vitamin d deficiency, obesity, vitamin d, female
3 authors
From CN
- Mei JiangBeijing University of Chinese Medicine
- Tan WangBeijing University of Chinese Medicine
- Ling Huang · correspondingBeijing University of Chinese Medicine
Abstract
Introduction
Vitamin D deficiency is linked to increased risk of polycystic ovary syndrome (PCOS) and may worsen metabolic disorders such as insulin resistance. However, evidence remains inconsistent regarding vitamin D status in non-obese women with PCOS. This study aimed to perform the first systematic review and meta-analysis evaluating serum vitamin D levels in non-obese PCOS patients.
Methods
Relevant studies were searched in PubMed, Embase, Cochrane Library, and Web of Science up to May 2025. Eligible studies comparing non-obese PCOS women and healthy controls were included. Two reviewers independently screened articles. Meta-analysis was conducted using a random-effects model, supplemented by subgroup, sensitivity, and publication bias analyses.
Results
Eleven studies involving 533 non-obese PCOS patients and 574 controls were included. No significant differences were found in serum 25(OH)D or 1,25(OH)2D levels between groups. Heterogeneity was mainly attributed to region, diagnostic criteria, BMI, and assay methods. Significant publication bias was detected.
Discussion
Serum vitamin D levels are not significantly associated with non-obese PCOS, implying vitamin D deficiency may be driven by obesity rather than PCOS pathogenesis. Vitamin D supplementation may benefit obese PCOS patients, and further prospective studies are needed.
Systematic review registration
http://www.crd.york.ac.uk/PROSPERO, identifier CRD420251168257.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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