Vitamin D Deficiency and Severe Dengue Fever: A Systematic Review and Meta-Analysis
Zhuang C, Yan X, Liang Y, Zhang L, Cai L, Lin Y, Feng X, Yan H
The American journal of tropical medicine and hygiene · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2026-07-02 · Am J Trop Med Hyg · vol. 115 · issue 3 · pp. 424–429
- Publisher
- American Society of Tropical Medicine and Hygiene
- Cited
- 0 citations · more than 50% of similar papers · 0.0× the field average
- References
- 0 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Mosquito-borne diseases and control
- Keywords
- Dengue fever, vitamin D deficiency, Vitamin D and neurology, Odds ratio, Observational study, Vitamin, Prospective cohort study
- MeSH
- humans, dengue, vitamin d deficiency, vitamin d, odds ratio, child, severe dengue
8 authors
From CN
- Chuchun ZhuangJinan University
- Xinxiaodi YanJinan University
- Yufeng LiangGuangzhou Center for Disease Control and Prevention
- Lihua ZhangGuangzhou Medical University
- Lian CaiGuangzhou Medical University
- Yukun LinGuangzhou Medical University
Abstract
Vitamin D affects immune function and possibly, dengue severity, but evidence is inconsistent. Observational studies comparing vitamin D levels between severe and nonsevere dengue were systematically searched. A random-effects meta-analysis was conducted. Heterogeneity was quantified using I2. Subgroup and sensitivity analyses were performed. Six studies with 1,130 participants were included. The pooled odds ratio (OR) for severe dengue with vitamin D deficiency was 1.77 (95% CI: 0.75-4.16, P = 0.194) with substantial heterogeneity (I2 = 61.6%). A subgroup analysis showed a significant association in children (OR: 51.20, 95% CI: 3.12-842.95). Excluding an outlier yielded a significant fixed-effect OR of 1.67 (95% CI: 1.04-2.67, P = 0.034) with reduced heterogeneity (I2 = 46.1%). Vitamin D deficiency might be linked to higher odds of severe dengue, especially in children, but confirmation requires larger sample sizes. Establishing causality and assessing vitamin D supplementation in high-risk groups require prospective studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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