The compliance patterns and personalized management of repeated red light therapy in children: A 4-year multicenter retrospective study
Liu G, Li N, Ma Y, Wang J, Song D, Wang B, Hu Y, Pei E, Tian Y, Yang J, Zhu Z, Du B, Wei R
iScience · 0 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Tianjin Medical University Eye Hospital
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-06-25 · iScience · vol. 29 · issue 7 · p. 116579
- Publisher
- Cell Press
- Cited
- 0 citations · more than 57% of similar papers · 0.0× the field average
- References
- 26 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Laser Applications in Dentistry and Medicine · Neonatal Health and Biochemistry · Dermatologic Treatments and Research
- Keywords
- Retrospective cohort study, Compliance (psychology), Multicenter study, Red light, Light therapy
13 authors
From CN, AU
- Guihua LiuTianjin Medical University Eye Hospital; Tianjin Medical University
- Na LiTianjin Medical University Eye Hospital; Tianjin Medical University
- Yuexuan MaTianjin Medical University Eye Hospital; Tianjin Medical University
- Jinghui WangTianjin Medical University Eye Hospital; Tianjin Medical University
- Desheng SongTianjin Medical University Eye Hospital; Tianjin Medical University
- Biying WangTianjin Medical University Eye Hospital; Tianjin Medical University
Abstract
Limited real-world evidence exists on how repeated red light therapy (RRLT) compliance influences axial elongation patterns across multiple years. This 4-year multicenter retrospective real-world study included 2575 children aged 6-16 years (spherical equivalent -10.00 D to +3.00 D) using home-based RRLT. The annual axial length (AL) elongation ≤0.10 mm defined favorable efficacy. After 4 years, the cumulative AL increase was 0.32 ± 0.02 mm. Higher cumulative compliance correlated with slower AL elongation (β = -0.322; p 24.00 mm; 10-13 years: >25.00 mm). Spline models identified that cumulative compliance levels of approximately 58%, 69%, 58%, and 67% were associated with favorable efficacy outcome over 1-4 years, respectively. These findings indicate that at least 58% cumulative compliance is necessary for a favorable long-term response. This study provides suggestions for personalized treatment strategies to balance efficacy and usage burden in children receiving RRLT.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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