Semaglutide-associated NAION: a proposed 'two-hit' model involving buried optic disc drusen and sustained hypohydration
Zhao G, Ma N, Yang Y, Yang A, Gao B
The British journal of ophthalmology · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2026-08-03 · Br J Ophthalmol · pp. bjo–2026
- Publisher
- BMJ
- Cited
- 1 citation · more than 97% of similar papers · 7.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 7 works
- Access
- Paywalled
- Research areas
- Intraoperative Neuromonitoring and Anesthetic Effects · Retinal and Optic Conditions · Drug-Induced Ocular Toxicity
- Keywords
- Optic nerve, Optic disc, Drusen, Optic neuropathy, Diabetes mellitus, Prospective cohort study, Eye disease, Diabetic retinopathy
5 authors
From CN
- Guohong ZhaoTang Du Hospital; Air Force Medical University
- Nan MaTang Du Hospital; Air Force Medical University
- Yan YangTang Du Hospital; Air Force Medical University
- Aili YangTang Du Hospital; Air Force Medical University
- Bin GaoTang Du Hospital; Air Force Medical University
Abstract
Semaglutide-associated non-arteritic anterior ischaemic optic neuropathy (NAION) mechanisms are unclear. We report a 28-year-old man with type 2 diabetes who developed right NAION 4-5 months after starting semaglutide. Multimodal imaging confirmed NAION and bilateral buried optic disc drusen. The affected eye was short, whereas the fellow eye was highly myopic and longer. Serial bioimpedance showed a 1.9 L decline in total body water over 7 weeks, with preserved fat mass and stable extracellular-to-total-body-water (ECW/TBW) ratio. We propose a hypothesis-generating 'two-hit' model in which anatomical susceptibility and sustained hypohydration together precipitate NAION. Heightened clinical awareness may be warranted and prospective studies are required.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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