Behavioral and autonomic effects of caffeine in normal boys
Rapoport JL, Elkins R, Neims A, Zahn T, Berg CJ
Developmental pharmacology and therapeutics · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-08-11 · Dev Pharmacol Ther · vol. 3 · issue 2 · pp. 74–82
- Publisher
- Karger Publishers
- Cited
- 39 citations · more than 73% of similar papers · 1.0× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts
- Keywords
- Caffeine, Placebo, Crossover study, Psychology, Autonomic nervous system, Medicine, Anesthesia, Internal medicine, Endocrinology, Heart rate, Blood pressure
- MeSH
- autonomic nervous system, saliva, humans, caffeine, diet, double-blind method, behavior, arousal, reaction time, manifest anxiety scale, dose-response relationship, drug, drug tolerance, child, male, skin physiological phenomena
5 authors
From US
- Judith L. RapoportNational Institute of Mental Health
- Robert ElkinsNational Institute of Mental Health
- Alan NeimsNational Institute of Mental Health
- Theodore P. ZahnNational Institute of Mental Health
- Carol J. Berg
Abstract
Following a 1-week baseline, 19 normal boys (mean age 9.8 +1.8 years) ingested either caffeine (5 mg/kg) or placebo twice a day for a 2-week period per condition in a double-blind crossover study (total study duration of 5 weeks) to study the behavioral, autonomic and side effects of caffeine. Mothers of the whole sample and children who were low caffeine users could distinguish between drug conditions by side effects. Caffeine increased autonomic reactivity of low users only. Behavioral and autonomic results were ambiguous for high users indicating possible caffeine withdrawal symptoms. While 'caffeinism' may occur in children, either self-selection and/or tolerance may prevent its occurrence in naturally selected diets.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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